Prof. Dr. S. Backert

Research areas: Host/pathogen interaction

Stable adhesion complexes are crucial for maintenance of the cell-to-cell integrity in healthy epithelia of humans and represent the first barrier for microbial pathogens. Alterations in these complexes are key events in the development and progression of many diseases including various cancers. One of the major proteins involved in maintaining epithelial adhesion is the tumor-suppressor and junctional transmembrane protein E-cadherin. E-cadherin also controls the transcription factor b-catenin and other signaling components, and is involved in cell morphogenesis, adhesion, recognition and communication. Inactivation of E-cadherin’s adhesive properties is often a key step in various infections, tumor progression and metastasis. We have recently identified a novel secreted effector protein, the serine protease HtrA, ofthe foodborne pathogen Campylobacter jejuni and the gastric pathogen and type-I carcinogen Helicobacter pylori. HtrA of these microbes can be secreted into the extracellular space where it can cleave-off the extracellular domain of E-cadherin on polarized gastric or intestinal epithelial cells. Since the htrA gene is conserved in many bacterial pathogens our findings could provide a potential novel mechanism how these microbes may destroy cellular junctions in mucosal epithelial cells, in order to get access to deeper tissues and cause disease by degrading E-cadherin and probably other cellular factors. This project is therefore designed to contribute to the understanding of mechanisms underlying basic HtrA functions in bacterial pathogenesis. In particular, we investigate the molecular mechanisms/requirements for HtrA proteolytic activity, pinpoint novel HtrA targets on host cells and to study downstream signaling events. In addition, we aim to identify the secretion pathway of HtrA across the two bacterial membranes because this could give hints how HtrA is transported. Our studies will take advantage of powerful technologies including fluorescence microscopy and live cell imaging as well as proteomics-based and cellular signal transduction approaches.

Helicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer. More virulent H. pylori isolates harbour numerous well-known adhesins (BabA/B, SabA, AlpA/B, OipA and HopZ) and the cag (cytotoxin-associated genes) pathogenicity island (PAI) encoding a type IV secretion system (T4SS). The adhesins establish tight bacterial contact with host target cells and the T4SS represents a needle-like pilus device for the delivery of effector proteins into host target cells such as CagA. BabA and SabA can bind to blood group antigen and sialylated proteins respectively, and a series of T4SS components including CagI, CagL, CagY and CagA have been shown to target the integrin β1 receptor followed by injection of CagA across the host cell membrane. The interaction of CagA with membrane-anchored phosphatidylserine may also play a role in the delivery process. While substantial progress has been made in our current understanding of many of the above factors, the host cell receptors for OipA, HopZ and AlpA/B during infection are still unknown. We are interested in characterizing the interactions of the various adhesins and structural T4SS proteins with host cell factors. Of particular interest is the T4SS encoded by the cagPAI. T4SSs are macromolecular assemblies used by numerous bacteria to transport molecules across their membranes including proteins and DNA. T4SS are generally composed of a set of 12 proteins (VirB1-11 and the VirD4 coupling factor) plus some accessory proteins. This together represents a dynamic membrane-anchored machinery powered by three encoded NTPases. Since T4SSs are widespread in many pathogenic bacteria where they are often used to deliver effectors into host cells, we investigate the unique and complex interaction of various components of the H. pylori T4SS as a model system. Its interaction with the integrin β1 receptor will help to better understand the molecular mechanisms of how protein translocation events work in H. pylori. We therefore use specific bacterial mutant strains, proteomics-based methods, protein-protein interaction studies such as Biacore and sophisticated microscopic technologies.

As Helicobacter pylori was the first bacterium cultivated from human gastric biopsy specimens in 1982, it has become apparent that Helicobacter subspecies exhibit a broad host spectrum and can be isolated from the gastrointestinal tracts of humans, non-human primates, cats, dogs, cheetahs, ferrets, rodents, cows, sheep, pigs, dolphins, and birds. Currently there are 32 validated Helicobacter species and several other described isolated candidates. Members of the genus Helicobacter are helical curved, spiral or fusiform, Gram-negative bacteria with or without helical periplasmic fibers. We are interested in the investigation and characterization of novel enterohepatic Helicobacter subspecies (EHS), which are an emerging group of microaerobic, motile pathogens carrying flagella with variable styles in number and locations. EHS are known to persistently colonize multiple animal species. They can be isolated from the lower intestine, hepatobiliary system, and diarrheic feces and are potentially associated with chronic inflammation and epithelial cell hyperproliferation leading to neoplasic disease. Helicobacter hepaticus, considered the prototype of all known EHS, has been shown to induce chronic active hepatitis and hepatocellular carcinoma in A⁄JCr and B6C3F1 mice strains as well as typhlocolitis in A⁄JCr inbred mice. This species is also used experimentally to induce cholesterol gallstones, inflammatory bowel disease (IBD), and in certain strains of mice induces colon cancer. Because lesions caused by EHS in mice often mimic those seen in humans with cholecystitis, their possible role in hepatobiliary disease in humans has been proposed. In addition, the possible zoonotic origin of important clinical manifestations in humans and the health status of mice housed in research facilities have recently attracted the attention of scientists. In contrast to H. pylori, almost nothing is known about potential virulence factors in EHS. To evaluate the prevalence of EHS infections in mouse strains harbored in specific-pathogen-free (SPF) facilities, we tested 40 mouse lines that were permanently living in nine colony rooms using a group-specific PCR, which detects all Helicobacter species currently known. When Helicobacter-negative and infected mice shared the same cage, transmission of the infection occurred within two weeks at very high frequency (100%). Furthermore, we found that mice from commercial breeding facilities may carry undetected Helicobacter infections. We also showed that infection with EHS may occur and spread frequently in mice under SPF conditions, and despite extensive safety conditions. Due to the lack of available methods, EHS infections often remain unrecognized but can cause severe health complications or more subtle host immune perturbations and therefore can confound the results of animal experiments. We therefore isolate and investigate live pathogens, and develop methods to rapidly identify novel EHS.


1.) Backert, S., Dörfel, P., Börner, T. (1995)
Investigation of plant organellar DNA by pulsed-field gel electrophoresis. Current Genetics 28: 390-399.

2.) Backert, S., Lurz, R., Börner, T. (1996)
Electron microscopic investigation of mitochondrial DNA from Chenopodium album (L.). Current Genetics 29: 427-436.

3.) Backert, S., Dörfel, P., Lurz, R., Börner, T. (1996)
Rolling circle replication in the mitochondria of the higher plant Chenopodium album (L.). Molecular and Cellular Biology 16: 6285-6294.

4.) Backert, S., Meißner, K., Börner, T. (1997)
Unique features of a mitochondrial rolling circle-plasmid mp1 from the higher plant Chenopodium album (L.). Nucleic Acids Research 25: 582-590.

5.) Backert, S., Lurz, R., Oyarzabal, O.A., Börner, T. (1997)
High content, size and distribution of single-stranded DNA in the mitochondria of Chenopodium album (L.). Plant Molecular Biology 33: 1037-1050.

6.) Backert, S., Dörfel, P., Börner, T. (1997)
Investigation of plant organellar DNA by pulsed-field gel electrophoresis, Tobacco Abstracts 84: 96-97.

7.) Oyarzabal, O.A., Wesley, L.V., Harmon, K., Lauerman, L.H., Barbaree, J. M., Tucker, L., Backert, S., Conner, D.E. (1997)
Specific identification of Campylobacter fetus by PCR targeting variable regions of the 16S rRNA. Journal of Veterinary Microbiology 58: 61-71.

8.) Scissum-Gunn, D.K., Gandhi, M., Backert, S., Nielsen, B.L. (1998)
Higher plant mitochondrial DNA can be resolved into distinct populations by field inversion gel electrophoresis. Plant Molecular Biology Reporter 16: 219-229.

9.) Gandhi, M., Hammett, L., Scissum-Gunn, K., Backert, S., Nielsen, B.L. (1998)
Analysis of genome structure and gene copy number in Brassica campestris mitochondrial DNA. FASEB Journal 12: 261-262.

10.) Backert, S., Kunnimalaiyaan, M., Börner, T., Nielsen, B.L. (1998)
In vitro replication of mitochondrial plasmid mp1 from the higher plant Chenopodium album (L.): A remnant of bacterial rolling circle and conjugativeplasmids? Journal of Molecular Biology 284: 1005-1015.

11.) Backert, S., von Nickisch-Rosenegk, E., Meyer, T.F. (1998)
Potential role of two Helicobacter pylori relaxases in DNA transfer? Molecular Microbiology 30: 673-674.

12.) Gratchev, A., Böhm, C., Riede, E., Foss H.D., Hummel, M., Mann, B., Backert, S.,
Buhr, H.J., Stein, H., Riecken, E.-O., Hanski, C. (1998)
Regulation of mucin MUC2 gene expression during colon carcinogenesis. Annals of the New York Academy of Sciences 859: 180-183.

13.) Gelos, M.,  Backert, S., Klussmann, E., Gratchev, A., Kobalz, U., Mann, B., Moyer, M.P.,
Böhm, C., Riecken, E.O., Hanski, C. (1998)
Detection of differential gene expression in colorectal cancer cell lines: comparison of three methods. Journal of Molecular Medicine 76: 13.

14.) Backert, S.,  Gelos, M.,  Kobalz, U., Hanski, M.L.,  Böhm, C.,  Mann, B.,  Lövin, N.,
Gratchev, A., Mansmann, U., Moyer, M.P., Riecken, E.O., Hanski, C. (1999)
Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array. International Journal of Cancer 82: 868-874.

15.) Backert, S., Börner, T. (2000)
Intermediates of replication and recombination in the mitochondria of the higher plant Chenopodium album (L.). Current Genetics 37: 304-314.

16.) Backert, S.,  Ziska, E., Brinkmann, V., Zimny-Arndt, U., Fauconnier, A., Jungblut, P.R.,
Naumann, M., Meyer, T.F. (2000)
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cellular Microbiology 2: 155-164.

17.) Backert, S.  (2000)
Strand-switching during rolling circle replication of plasmid-like DNA minicircles in the mitochondria of the higher plant Chenopodium album (L.). Plasmid 43: 166-170.

18.) Ramarao, N., Gray-Owen, S.D., Backert, S., Meyer, T.F. (2000)
Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV  secretion components. Molecular Microbiology 37: 1389-1404.

19.) Backert, S., Müller, E.-C., Jungblut, P.R., Meyer, T.F. (2001)
Tyrosine phosphorylation patterns and size modification of the Helicobacter pylori CagA protein after translocation in gastric epithelial cells. Proteomics 1: 608-617.

20.) Moese, S., Selbach, M., Zimny-Arndt, U., Jungblut, P.R., Meyer, T.F., Backert, S. (2001)
Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of  the Helicobacter CagA protein in phagocytic cells. Proteomics 1: 618-629.

21.) Backert, S., Moese, S., Selbach, M., Meyer, T.F. (2001)
Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Molecular Microbiology 42: 631-644.

22.) Kwok, T., Backert, S., Schwarz, H., Berger, J., Meyer, T.F. (2002)
Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infection & Immunity 70, 2108-2120.

23.) Selbach, M., Moese, S., Meyer, T.F., Backert, S. (2002)
Functional analysis of Helicobacter pylori cag pathogenicity island reveal VirD4/CagA-dependent and VirD4/CagA-independent mechanisms. Infection & Immunity 70: 665-671.

24.) Selbach, M., Moese, S., Hauck, C.R., Meyer, T.F., Backert, S. (2002)
Src is the kinase of the Helicobacter pylori CagA protein in vivo and in vitro. Journal of Biological Chemistry 277: 6775-6778.

25.) Moese, S., Selbach, M., Meyer, T.F., Backert, S. (2002)
cag+ Helicobacter pylori induce a homotopic aggregation phenotype in macrophage-like cells by recruitment of ICAM-1 to the cell surface. Infection & Immunity 70: 4687-4691.

26.) Backert, S.  (2002)
R-loop dependent rolling-circle replication and a new model for DNA concatemer resolution by mitochondrial plasmid mp1. EMBO Journal 21: 3128-3136.

27.) Selbach, M., Moese, S., Hauck, C.R., Meyer, T.F., Backert, S. (2003)
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin cytoskeletal rearrangements by inactivation of c-Src. EMBO Journal 22: 515-528.

28.) Zawilak, A., M.C. Durrant, P. Jakimowicz, S. Backert, J. Zakrzewska-Czerwińska (2003)
DNA binding specificity of the replication initiator protein, DnaA from Helicobacter pylori. Journal of Molecular Biology 334: 933-947.

29.) Backert, S., Schwarz, T., Sommer, Ch., Kirsch, C., Kwok, T., Goebel, U., Lehn, N.,
Miehlke, S., König, W., Meyer, T.F. (2004)
Function of the cag pathogenicity island in Helicobacter pylori isolated from patients with gastritis, peptic ulcer and gastric cancer. Infection & Immunity 72:1043-1056.

30.) Moese, S., Selbach, M. Kwok, T., König, W., Meyer, T.F. Backert, S. (2004)
Helicobacter pylori induces AGS cell motility and elongation via independent pathways. Infection & Immunity 72:3646-3649.

31.) Selbach, M., Moese, S., Backert, S., Jungblut, P.R., Meyer, T.F. (2004)
The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin. Proteomics 4, 2961-2968.

32.) Backert, S., Gressmann, H., Kwok, T., König, W., Jungblut, P.R.; Meyer, T.F. (2005)
Gene expression and protein profiling of AGS gastric epithelial cells upon infection with Helicobacter pylori. Proteomics 5: 3902-3918.

33.) Backert, S., Zimny-Arndt, U., Schmid, M., Kwok, T., Peek, R., König, W., Meyer, T.F.,
Jungblut, P.R. (2005)
Subproteomes of soluble and structure-bound Helicobacter pylori proteins analysed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 5: 1331-1345.

34.) Enarsson, K., Innocenti-Brisslert, M., Backert, S., Quiding-Järbrink, M. (2005)
Helicobacter pylori induce transendothelial migration of activated memory T cells. Infection & Immunity 73: 761-769.

35.) Brisslert, M., Enarsson, K., Lundin, B.S., Karlsson, A., Kusters J., Svennerholm, A.-M.,
Backert, S., Quiding-Järbrink, M. (2005)
Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP. FEMS Microbiology Letters 249: 95-103.

36.) Gieseler, S., König, B., König, W., Backert, S. (2005)
Strain-specific expression profiles of virulence genes in Helicobacter pylori during infection of gastric epithelial cells and granulocytes. Microbes & Infection 7: 437-447.

37.) Backert, S., Kwok, T., König, W. (2005)
Conjugative plasmid DNA transfer in Helicobacter pylori mediated by chromosomally encoded relaxase and TraG-like proteins. Microbiology 151(Pt 11): 3493-3503.

38.) Brandt, S., Kwok, T., Hartig, R., König, W., Backert, S. (2005)
NF-B-activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proceedings of the National Academy of Sciences USA102: 9200-9205.

39.) Dossumbekova, A., Prinz, C., Gerhard, M., Brenner, L., Backert, S., Kusters, J.G.,
Schmid, R.M., Rad, R. (2006)
Helicobacter pylori outer membrane proteins and gastric inflammation. Gut 55:1360-1361.

40.) Dossumbekova, A., Prinz, C., Mages, J., Lang, R., Kusters, J.G.,  vanVliet, A.H.,
Reindl, W.,Backert, S., Aur, D., Schmid, R.M., Rad, R. (2006)
Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. Journal of Infectious Diseases 194:1346-1355.

41.) Backert, S. (2006)
Interaction of Helicobacter pylori with its host: role of the cag pathogenicity island and multiple functions of the CagA protein. European Journal of Cell Biology 85 (Suppl.): 117-118.

42.) Bohr, U. R. M., Selgrad, M., Ochman, C., Backert, S. , König, W., Fenske, A., Wex, T.,
Malfertheimer, P. (2006) Prevalence and spread of enterohepatic Helicobacter in mice reared in a specific pathogen-free facility. Journal of Clinical Microbiology 44, 738-742.

43.) Krause, M., Hartig, R., Miller, W.G., Schmidt, G., König, W., Backert, S. (2007)
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni. Cellular Microbiology 9: 2431-2444.

44.) Krause, M., Oyarzabal, O.A., Alter, T. Hänel, I., Schliephake, A., König, W., van
Lieke, A., van Putten, J., Konkel, M., Backert, S. (2007)
Campylobacter jejuni and Campylobacter coli. FEMS Microbiology Letters 274: 9-16.

45.) Oyarzabal, O.A., Rad, R., Backert, S. (2007)
Conjugative Transfer of a Chromosomally-Encoded Antibiotic Resistance from Helicobacter pylori into Campylobacter jejuni. Journal of Clinical Microbiology 45:402-408.

46.) Oyarzabal, O.A., Backert, S., Nagaraj, M., Miller, R.S., Hussain, K.S., Oyarzabal, E.A. (2007)
Efficacy of Supplemented Buffered Peptone Water for the Isolation of Campylobacter jejuni and C. coli from Broiler Retail Products. Journal of Microbiological Methods 69: 129-136.

47.) Brandt, S., Shafikhani, S., Balachandran, P., Jin, S., Hartig, R., König, W., Backert, S. (2007)
Use of a novel co-infection system reveals a role for Rac, Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunology and Microbiology 50: 190-205.

48.) Blumenthal, B., Hoffmann, C., Aktories, K., Backert, S., Schmidt, G. (2007)
The Cytotoxic Necrotizing Factors from Yersinia pseudotuberculosis (CNFY) and from Escherichia coli (CNF1) Bind to Different Cellular Receptors but Take the Same Route to the Cytosol. Infection & Immunity 75: 3344-3353.

49.) Moese, S., Selbach, M., Brinkmann, V., Karlas, A., Haimovich, B., Backert, S., Meyer, T.F. (2007)
The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cellular Microbiology9: 1148-1161.

50.) Tammer, I., Brandt, S., Hartig, R., König, W., Backert, S. (2007)
Activation of c-Abl kinase by Helicobacter pylori: a novel kinase of the CagA protein and crucial mediator of host cell scattering. Gastroenterology132: 1309-1319.

51.) Potturi-Venkata, .LP., Backert, S., Vieira, S.L., Oyarzabal, O.A. (2007)
Campylobacterspp. Journal of Food Protection 70: 2549-  2554.

52.) Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R.,
Berger, J., Sewald, N., König, W., Backert, S. (2007) Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449: 862-866.

53.) Potturi-Venkata, L.P., Backert, S., Lastovica, A.J., Vieira, S.L., Norton, R.A., Miller,
Campylobacterspecies from live broilers. Poultry Science 86: 1304-1311.

54.) Knauer, O., Binai, N.A., Carra, G., Beckhaus, T., Hanschmann, K.M., Renné, T.,
Backert, S., Karas, M., Wessler, S. (2008)
Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori-induced cytoskeleton turnover in gastric epithelial cells. Cellular Microbiology10: 2285-2296.

55.) Oyarzabal, O.A., Backert, S., Williams, L.L., Lastovica, A.J., Miller, R.S., Pierce, S.J.,
Vieira, S.L., Rebollo-Carrato, F. (2008)
Campylobacterjejunistrains isolated from commercial broilers in Puerto Rico. Journal of Applied Microbiology 105: 800-812.

56.) Speegle, L., Miller, M.E., Backert, S., Oyarzabal, O.A. (2009)
Campylobacter spp.from naturally contaminated retail broiler meat. Journal of Food Protection 72: 2592-2596.

57.) Tegtmeyer, N., Backert, S. (2009)
CELL host & microbe 5: 514-516.

58.) Brandt, S., Kenny, B., Rohde, M., Martinez-Quiles, N., Backert, S. (2009)
EPEC-Tir-injected effector protein in regulating Rac1 function. Cellular Microbiology11: 1254-1271.

59.) Brandt, S., Wessler, S., Hartig, R., Backert, S. (2009)
Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: role in AGS epithelial cell scattering and elongation. Cell Motility and the Cytoskeleton 66: 874-892.

60.) Svensson, H., Hansson, M., Kilhamn, J., Backert, S., Quiding-Järbrink, M. (2009)
Selective upregulation of endothelial E-selectin in response to Helicobacter pylori-induced gastritis. Infection and Immunity 77: 3109-3116.

61.) Selbach, M., Paul, F.E., Brandt, S., Guye, P., Daumke, O., Backert, S., Dehio, C.,
Mann, M. (2009)
CELL host & microbe 5: 397-403.

62.) Tegtmeyer, N., Zabler, D., Schmidt, D., Hartig, R., Brandt, S., Backert, S. (2009)
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cellular Microbiology 11: 488-505.

63.) Sason, H., Milgrom, M., Weiss, A.M., Melamed-Book, N., Balla, T., Grinstein, S.,
Backert, S., Rosenshine, I., Aroeti, B. (2009)
Escherichiacolisubverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Molecular Biology of the Cell20: 544-555. Erratum in: Molecular Biology of the Cell 20: 2638.

64.) Manchekar, M., Scissum-Gunn, K.D., Hammett, L.A., Backert, S., Nielsen, B.L. (2009)
Mitochondrial DNA recombination in Brassica campestris. Plant Science 177: 629-635.

65.) Olofsson, A., Vallström, A., Petzold, K., Tegtmeyer, N., Schleucher, J., Carlsson, S.,
Haas, R., Backert, S., Wai, S.N., Gröbner, G., Arnqvist, A. (2010) Biochemical and functional characterization of Helicobacter pylori vesicles. Molecular Microbiology 77: 1539-1555.

66.) Backert, S., Tegtmeyer, N., Selbach, M. (2010)
HelicobacterpyloriCagA effector protein functions: The master key hypothesis. Helicobacter 15: 163-176.

67.) Tegtmeyer, N., Hartig, R., Delahay, R.M., Rohde, M., Brandt, S., Conradi, J.,
Takahashi, S., Smolka, A.J., Sewald, N., Backert, S. (2010)
Journal of Biological Chemistry285: 23515-23526.

68.) Saha, A., Backert, S., Hammond, C.E., Gooz, M., Smolka, A.J. (2010)
Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology 139: 239-248.

69.) Hoy, B., Löwer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Plattner, P.,
Sewald, N., Backert, S., Schneider, G., Wessler, S. (2010)
Helicobacter pylori HtrA is a novel secreted virulence factor which cleaves E-Cadherin to disrupt intercellular adhesion. EMBO Reports 11: 798-804.

70.) Rivas Traverso, F., Bohr, U.R.M., Oyarzabal, O.A., Rohde, M., Clarici, A., Wex, T.,
Kuester, D., Malfertheiner, P., Fox, J.G., Backert, S. (2010)
Morphological, genetic and biochemical characterization of Helicobacter magdeburgensis, a novel species isolated from the intestine of laboratory mice. Helicobacter 15:403-415.

71.) Pachathundikandi, S., Brandt, S., Madassery, J., Backert, S. (2011)
Induction of Toll-like receptors 2 and 5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. PLosOne 6:e19614. Erratum in: Plos One 10: e0141721.

72.) Zhou, P., Hussain, S.K., Liles, M.R. Arias, C.R. Backert, S., Kieninger, K., Oyarzabal, O.A. (2011)
Enrichment Broths Produce Sufficient Microaerobic Conditions for the Effective Growth of Campylobacter spp. from Retail Broiler Meat. BMC Microbiology 11:175.

73.) Oelkers, M., Jakob, S., Lai, F.P.L., Block, J., Szczodrak, M., Kerkhoff, E., Backert, S.,
Schlueter, K., Stradal, T.E.B., Small, J.V. Koestler, S., Rottner, K. (2011) Microtubules as platforms for assaying actin polymerization in vivo. PLosOne 6: e19931.

74.) Tegtmeyer, N., Wittelsberger, R., Hartig, R., Martinez-Quiles, N., Backert, S. (2011) Serine phosphorylation of cortactin by ERK1/2 controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. CELL host & microbe 9: 520-531.

75.) Krause, M., Boehm, M., Rohde, M., Tegtmeyer, N., Takahashi, S., Buday, L., Oyarzabal, O.A, Backert, S. (2011)
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. Cell Communication & Signalling 9: 32.

76.) Boehm, M., Krause, M., Rohde, M., Tegtmeyer, N., Takahashi, S., Oyarzabal, O.A, Backert, S. (2011)
Major host factors in host cell invasion of Campylobacter jejuni: Role of fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1. Frontiers in Cellular & Infection Microbiolgy 1: 17.

77.) Hoy, B., Geppert, T., Reisen, F., Boehm, M., Plattner, P., Gadermaier, G., Sewald, N.,
Ferreira, F., Briza, P., Schneider, G., Backert, S., Wessler, S. (2012)
Distinct roles of HtrA proteases from different Gram-negative bacteria in cleaving the junctional protein and tumor suppressor E-cadherin. Journal Biological
Chemistry 287: 10115-10120.

78.) Roure, S., Bonis, M., Chaput, C., Ecobichon, C., Barrière, C., Geldmacher, N.,
Guadagnini, N., Schmitt, C., Prévost, M.-C., Labigne, A., Backert, S., Ferrero, R.L. Boneca, I.G. (2012)
Peptidoglycan maturation enzymes control flagellar functionality in bacteria. Molecular Microbiology 86: 845-856.

79.) Conradi, J., Huber, S., Gaus, K., Mertink, F., Gracia, S.R., Strijowski, U., Backert, S., Sewald, N. (2012)
Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrin alphaV beta3. Amino Acids43: 219-232.

80.) Wiedemann, T., Hofbaur, S., Tegtmeyer, N., Huber, S., Sewald, N., Wessler, S.,
Backert S., Rieder G. (2012)
Helicobacter pylori CagL-dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut 61: 986-996.

81.) Mueller, D., Tegtmeyer, N., Brandt, S., Yamaoka, Y., De Poire, E., Sgouras, D.,
Wessler, S., Torres, J., Smolka, A., Backert, S. (2012)
Hierarchic phosphorylation of the Helicobacter pylori CagA effector protein by Src and Abl tyrosine kinases. Journal of Clinical Investigation 122: 1553-1566.

82.) Boehm, M., Hoy, B., Rohde, M., Tegtmeyer, N., Bæk, K.T., Oyarzabal, O.A.,
Brøndsted, L., Wessler, S., Backert, S. (2012)
Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin. Gut Pathogens 25: 3.

83.) Conradi, J., Tegtmeyer, N., Huber, S., Gaus, K., Mertink, F., Gracia, S.R.,
Strijowski, U., Sewald, N., Backert, S. (2012)
An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA. Frontiers Cellular Infection Microbiology 2: 70.

84.) Hirsch, C., Tegtmeyer, N., Rohde, M., Rowland, M., Oyarzabal, O.A., Backert, S.,
Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth. Journal Gastroenterology 47: 936-940.

85) Tegtmeyer, N., Rivas Traverso, F., Rohde, M., Oyarzabal, O.A., Lehn, N., Berg. D.E.,
Fox, J.G., Backert, S. (2013)
Electron microscopic, genetic and biochemical characterization of a novel Helicobacter isolates in Bengal tigers. Plos One 8: e71220.

86.) Kim, D.J., Park, J.H., Franchi, L., Backert, S., Núñez, G. (2013)
Helicobacterpylori infected dendritic cells. European Journal of Immunology 44: 2197.

87.) Patel, S.R., Smith, K., Letley, D.P., Cook, K.W., Memon, A.A., Ingram,
R.J., Staples E., Backert, S., Zaitoun, A.M., Atherton, J.C., Robinson, K. (2013)
Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion. Cellular Microbiology 5: 2080-2092.

88.) Barden, S., Lange, S., Tegtmeyer, N., Conradi, J., Sewald, N., Backert, S., Niemann, H.H. (2013)
Helicobacter pylori type IV secretion system pilus protein CagL. Structure 21: 1931-1941.

89.) Lind, J., Backert, S., Pfleiderer, K., Berg, D.E., Yamaoka, Y., Sticht, H., Tegtmeyer, N.(2014)
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS One 9: e96488.

90.) Tegtmeyer, N., Lind, J., Schmid, B., Backert, S. (2014)
Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells. PLoS One 9: e97782.

91.) Heimesaat, M.M., Fischer, A., Alutis, M., Grundmann, U., Boehm, M.,
Tegtmeyer, N., Göbel, U.B., Kühl, A.A., Bereswill, S., Backert, S. (2014)
Campylobacter jejuniinfection of infant mice. Gut Pathogens 6: 16.

92.) Heimesaat, M.M., Alutis, M., Grundmann, U., Fischer A, Tegtmeyer N, Böhm M,
Kühl, A.A., Göbel, U.B., Backert, S., Bereswill, S. (2014)
Campylobacter jejuniinfection of gnotobiotic IL-10 deficient mice. Frontiers in Cellular and Infection Microbiology 4: 77.

93.) Zhang, Y.M., Noto, J.M., Hammond, C.E., Barth, J.L., Argraves, W.S., Backert, S.,
Peek,R.M. Jr., Smolka, A.J. (2014)
Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA. American Journal of Physiology – Gastrointestinal and Liver Physiology 306: G606-613.

94.) Barden, S., Schomburg, B., Conradi, J., Backert, S., Sewald, N., Niemann, H.H. (2014)
Helicobacter pylori type IV secretion system pilus protein CagL. Acta Crystallographica Section D: Biological Crystallography 70(Pt 5): 1391-1400.

95.) Tenguria, S., Ansari, S.A., Khan, N., Ranjan, A., Devi, S., Tegtmeyer, N., Lind, J.,
Backert, S., Ahmed, N. (2014)
Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase. International Journal of Medical Microbiology 304: 1066-1076.

96.) Zhang, X.S., Tegtmeyer, N., Traube, L., Jindal, S., Perez-Perez, G., Sticht, H., Backert,S., Blaser, M.J. (2015)
Helicobacter pylori CagA Epithelial Cell Interactions. PLoS Pathogens 11: e1004621.

97.) Boehm, M., Lind, J., Backert, S., Tegtmeyer, N. (2015)
Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration. European Journal of Microbiology and Immunology 5:68-80.

98.) Koch, K.N., Hartung, M.L., Urban, S., Kyburz, A., Bahlmann, A.S., Lind, J., Backert,S., Taube, C., Müller, A. (2015)
Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. The Journal of Clinical Investigation 125:3297-3302.

99.) Perna, A.M., Rodrigues, T., Schmidt, T.P., Böhm, M., Stutz, K., Reker, D., Pfeiffer,
B., Altmann, K.H., Backert, S., Wessler, S., Schneider, G. (2015)
Helicobacter pylori HtrA. Angewandte Chemie International Edition in English 54:10244-10248.

100.) Hammond, C.E., Beeson, C., Suarez, G., Peek, R.M. Jr., Backert, S., Smolka, A.J. (2015)
Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. American Journal of Physiology-Gastrointestinal and Liver Physiology 309:G193-201.

101.) Hartung, M.L., Gruber, D.C., Koch, K.N., Grüter, L., Rehrauer, H., Tegtmeyer, N.,Backert, S., Müller, A. (2015) H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-kB target gene expression. Cell Reports 13:70-79.

102.) Lind, J., Backert, S., Hoffmann, R., Eichler, J., Yamaoka, Y., Perez-Perez, G.I., Torres, J., Sticht, H., Tegtmeyer, N. (2016) Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains. BMC Microbiology (in press).

103.) Tegtmeyer, N., Moodley, Y., Yamaoka, Y., Pernitzsch, S.R., Schmidt, V., Rivas Traverso, F., Schmidt, T.P., Rad, R.,Yeoh, K.G.,Bow, H., Torres, J., Gerhard, M., Schneider, G., Wessler, S., Backert, S. (2016) Characterization of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA. Molecular Microbiology 99: 925-944.

104.) Pachathundikandi, S.K., Backert, S. (2016) Differential expression of IL-1β during Helicobacter pylori infection of TLR2- and TLR10-expressing HEK293 cell lines. J Infect Dis. Apr 18. pii: jiw154.

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Review Articels

105.) Backert, S., Nielsen, B.L., Börner, T. (1997)
The mystery of the rings: structure and replication of the mitochondrial genome in
higher plants, Trends in Plant Sciences  2: 477-483.

106.) Backert, S., Churin, Meyer, T.F. (2002)
Helicobacter pylori type IV secretion, host cell signalling and vaccine development. Keio Journal of Medicine 51 Suppl. 2: 6-14.

107.) Selbach, M., Backert, S. (2005)
Cortactin: an Achilles´ heel of the actin cytoskeleton. Trends in Microbiology 13: 181-189.

108.) König, W., H. Lauf, U. Arnold, I. Tammer, B. Ghebremedhin, A. Clarici,
F.L. Thies, A. Drynda, A. Schmalcz, T. Kwok, R. Arnold, S. Backert,
H. Werchau und B. König (2004)
Natürliche und adaptive Immunität des Respirationstraktes – Bedeutung mikrobieller Faktoren für Infektabwehr und Sensibilisierung, Atemwegs & Lungenkrankungen, 30, Teil 1 Nr. 11: 551–568.

109.) König, W., Lauf, H., Arnold, U., Tammer, I., Ghebremedhin, B., Clarici,A.,
Thies, F.L., Drynda, A., Schmalcz, A., Kwok, T., Arnold, R., Backert, S.,
Werchau, H., König, B. (2004)
Natürliche und adaptive Immunität des Respirationstraktes – Bedeutung mikrobieller Faktoren für Infektabwehr und Sensibilisierung, Atemwegs & Lungenkrankungen 30, Teil2 Nr. 12: 605-620.

110.) König, W., H. Lauf, U. Arnold, I. Tammer, B. Ghebremedhin, A. Clarici, F.L. Thies,
A. Drynda, A. Schmalcz, T. Kwok, R. Arnold, Backert, S., H. Werchau und B. König (2005)
Natürliche und adaptive Immunität des Respirationstraktes – Bedeutung mikrobieller Faktoren für Infektabwehr und Sensibilisierung, Atemwegs & Lungenkrankungen 31, Teil3 Nr. 4: 188-203.

111.) Backert, S., Selbach, M. (2005)
Tyrosine-phosphorylated microbial effector proteins: the enemies within. Trends in Microbiology 13: 476-484.

112.) Backert, S., König, W. (2005)
Interplay of bacterial toxins with host defence: molecular mechanisms of immunomodulatory signaling. International Journal of Medical Microbiology 295: 519-530.

113.) Backert, S., Meyer, T.F. (2006)
Type IV secretion systems and their effector proteins in bacterial pathogenesis. Current Opinion in Microbiology 9: 207-217.

114.) Backert, S., Fischer, W. (2007)
Transport von Proteinen und DNA: Typ IV-Sekretion bei Gram-negativen Bakterien. Naturwissenschaftliche Rundschau 60: 10-17.

115.) Backert, S., Feller, S.M., Wessler, S. (2008)
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Trends in Biochemical Sciences 33: 80-90.

116.) Hänel, I., Alter, T., Backert, S. (2008)
25th Jenaer Symposium: Campylobacter Infections. Bundesgesundheitsblatt
Gesundheitsforschung Gesundheitsschutz. 51: 1347-1352.

117.) Wessler, S., Backert, S. (2008)
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Trends in Microbiology 16: 397-405.

118.) Backert, S., Selbach, M. (2008)
Role of type IV secretion in Helicobacter pylori pathogenesis. Cellular Microbiology 10: 1573-1581.

119.) Torres, J., Backert, S. (2008)
Pathogenesis of Helicobacter pylori infection. Helicobacter 13 (Suppl. 1):13-17.

120.) Backert, S., Fronzes, R., Waksman, G. (2008)
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems, Trends in Microbiology 16: 409-413.

121.) Backert, S., Kenny, B., Gerhard, R., Tegtmeyer, N., Brandt, S. (2010) PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function. Gut Microbes 1: 94-99.

122.) Backert, S., Tegtmeyer, N. (2010)
The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal
Transduction and Molecular Crosstalk. Toxins 2: 69-92.

123.) Stradal. T.E.B., Backert, S. (2010)
Wie EHEC das Aktinzytoskelett der Wirtszelle beeinflussen. Biospektrum 16: 624-627.

124.) Backert, S., Naumann, M., (2010)
What a disorder: pro-inflammatory signaling during Helicobacter pylori infections. Trends in Microbiology 18: 479-486.

125.) Tegtmeyer, N., Backert, S., (2011)
Role of Abl and Src family kinases in actin-cytoskeletal rearrangementsinduced by
the Helicobacter pylori CagA protein. European Journal of Cell Biology 90: 880-890.

126.) Backert, S., Clyne., M (2011)
Pathogenesis of Helicobacter pylori infection. Helicobacter 16: 19-25.

127.) Backert, S., Clyne, M., Tegtmeyer, N. (2011)Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Communication & Signaling 9: 28-35.

 128.) Tegtmeyer, N., Wessler, S., Backert, S. (2011)Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS Journal 278: 1190-1202.

129.) Ó Cróinín, T., Backert, S. (2012)
Host epithelial cell invasion by Campylobacter jejuni: trigger or zipper mechanism?
Frontiers in Cellular & Infection Microbiology 2:25.

130.) Gölz, S., Sharbati, S., Backert, S., T. Alter (2012)
Quorum sensing dependant phenotypes and their molecular mechanisms in
Campylobacterales. European Journal of Microbiology & Immunology 2:50-60.

131.) Backert, S., Tegtmeyer, N. (2012)
 Helicobacter pylori CagA tertiary structure reveals functional insights. CELL host &
 microbe 12: 3-5.

132.) Smolka, A., Backert, S. (2012)
How Helicobacter pylori infection controls gastric acid secretion. Journal of Gastroenterology 47: 609-618.

133.)  Backert, S., Hofreuter, D. (2013)
Molecular methods to investigate adhesion, transmigration, invasion and intracellular survival of the foodborne pathogen Campylobacter jejuni. Journal of Microbiological Methods 95: 8-23.

134.)  Backert, S., Boehm, M., Wessler, S., Tegtmeyer, N. (2013) Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both? Cell Communication and Signaling 11: 72.

135.) Posselt, G., Backert, S., Wessler, S. (2013)The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Communication and Signaling 11: 77.

136.) Pachathundikandi, S.K., Tegtmeyer, N., Backert, S. (2013) Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes 4: 454-474.

137.) Fernandez-Gonzalez, E., Backert, S. (2014)
DNA transfer in the gastric pathogen Helicobacter pylori. Journal of Gastroenterology 49: 594-604.

138.) Pachathundikandi, S.K., Lind, J., Tegtmeyer, N., El-Omar, E.M., Backert, S. (2015)
Interplay of the gastric pathogen Helicobacter pylori with toll-like receptors. BioMedical Research International 2015:192420.

139.) Backert, S., Tegtmeyer, N., Fischer, W. (2015)
Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiology 10:955-965.

140.) Backert, S., Neddermann, M., Maubach, G., Naumann, M. (2016)
Pathogenesis of Helicobacter pylori infection. Helicobacter (in press).

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Books and book chapters

141.) Backert, S. (1996) Untersuchungen zur Struktur und Replikation des Mitochondriengenoms von
Chenopodium album (L.), Shaker-Verlag, Aachen (ISBN-Nr.:3-8265-1383-5).

142.) Backert, S., Moyer, P., Böhm, C., Riecken, E.-O., Hanski, C. (1998)
Differential gene expression in cell lines derived from colon carcinoma or normal
colonic mucosa, Jahrbuch der 8. Wissenschaftswoche an der FU-Berlin (ISBN-Nr.: 3-9806076-5-8): pp. 45-46.

143.) Backert, S., König, W., Arnold, R., König, B. (2006)
Induction and modulation of inflammatory networks by bacterial protein toxins. In
“The Sourcebook of Bacterial Protein Toxins”, edited by J. E. Alouf, M. R. Popoff,
Academic Press, New York. Section V, Chapter 54: pp. 887-918.

144.) Backert, S., H. Mimuro, D.A. Israel, R.M. Peek jr.  (2010)
Virulence factors in Helicobacter pylori, in: Helicobacter pylori in the 21st century.
CABI-Verlag, edited by: P. Sutton and H.M. Mitchell, pp. 212-247.

145.) Wessler, S., Backert, S., (2011)
The Abl Family of Tyrosine Kinases and Microbial Pathogenesis. International Reviews in Cell and Molecular Biology 286, Elsevier, edited by Kwang W. Jeon 271-300.

146.) Oyarzabal, O.A., Backert, S.  Eds. (2012)
Microbial Food Safety, Springer New York, ISBN-Nr.: 978-1-4614-1176-5.

147.) Tegtmeyer, N., Rohde, M., Backert, S.  (2012)
Clinical presentations and pathogenicity mechanisms of bacterial foodborne diseases. In “Microbial Food Safety”, Springer New York, edited by O.A. Oyarzabal & S. Backert.

148.) Oyarzabal, O.A., Backert, S.  (2012)
Food safety resources. In “Microbial Food Safety”, Springer New York, edited
by O.A. Oyarzabal & S. Backert.

149.) Backert, S., Zanotti, G., Lind, J., Asche, C.I., Tegtmeyer, N. (2016)
Roles of the cagPAI and CagA on gastroduodenal diseases. In “Helicobacter pylori research: from bench to bedside”, Springer New York, edited by S. Backert & Y. Yamaoka, ISBN-10: 4431559345.

150.) Backert, S., Y. Yamaoka  (2016)
Helicobacter pylori research: from bench to bedside”, Springer Tokio, edited
by S. Backert & Y. Yamaoka, ISBN-10: 4431559345.

151.) Omar A. Oyarzabal, O.A., Backert, S. (2016)
Control of Campylobacter spp. in Commercial Poultry Production. In “Campylobacter spp. and related organisms in poultry: relationship pathogen host, diagnosis and epidemiology”, Springer New York, edited by B.B. Fonseca, D.A. Rossi & H. Fernandez (in press).

152.) Oyarzabal, O.A., Backert, S. (2016)
Varying pathogenicity of Campylobacter jejuni isolates. In “Foodborne Pathogens: Virulence Factors and Host Susceptibility”, Springer New York, edited by J. Gurtler (in press).

153.) Backert, S., Tegtmeyer, N., O’Croinin, T., Böhm, M., Heimesaat, M. (2016)
Human Campylobacteriosis. In ”Features, Detection and Prevention of Foodborne Disease: Campylobacter”, Elsevier, edited by  G. Klein (in press).

154.) Backert, S. (2016)
“Inflammasome signalling and bacterial infections”, Springer Heidelberg, edited
by S. Backert (in press).

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Published Abstracts (Web of Science)

155.)Development and characterization of an inducible genetic system in Helicobacter pylori to express a peptide inhibitor of serine protease HtrA
By: Tegtmeyer, N.; Boehm, M.; Backert, S.
HELICOBACTER  Volume: 21   Special Issue: SI   Supplement: 1   Pages: 84-85   Meeting Abstract: W4.2   Published: SEP 2016

156.) Genetic and functional analyses reveal high conservation and crucial role of Helicobacter pylori serine protease HtrA
By: Tegtmeyer, N.; Backert, S.
HELICOBACTER  Volume: 21   Special Issue: SI   Supplement: 1   Pages: 121-121   Meeting Abstract: P04.13   Published: SEP 2016

157.)Amino-terminal processing of Helicobacter pylori serine protease HtrA: role in oligomerization and regulating activity
By: Albrecht, N.; Tegtmeyer, N.; Sticht, H.; et al.
HELICOBACTER  Volume: 21   Special Issue: SI   Supplement: 1   Pages: 124-124   Meeting Abstract: P04.19   Published: SEP 2016

158.)A novel Helicobacter pylori CagL-alpha v beta 5-integrin-ILK signaling complex induces hypergastrinemia – a precancerous condition in the stomach
By: Wiedemann, T.; Hofbaur, S.; Wessler, S.; et al.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY  Volume: 302   Supplement: 1   Pages: 27-27   Published: SEP 2012

159.) HtrA: a new secreted virulence factor in bacterial infections
By: Hoy, B.; Backert, S.; Schneider, G.; et al.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY  Volume: 302   Supplement: 1   Pages: 128-128   Published: SEP 2012

160.) Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum.
By: Boehm M, Haenel I, Hoy B, Brøndsted L, Smith TG, Hoover T, Wessler S, Tegtmeyer N.
Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):163-73. doi: 10.1556/EuJMI.3.2013.3.3. Epub 2013 Sep 23.

Prof. Dr. Steffen Backert